As part of a continuous effort at North Carolina State University, research was conducted from 2007–2009 to establish the maximum expected pesticide residue on flue-cured tobacco that would result from a maximum labeled application rate and minimum preharvest interval of specific crop protection agents (CPAs). Residues of azoxystrobin, butralin, and flumetralin were measured on flue-cured tobacco over 6 environments in North Carolina during the research cycle. Butralin and flumetralin were applied via broadcast (BC) and downstalk (DS) application. Treatments were applied to tobacco grown on research stations near Clayton and Kinston, NC. Tobacco was managed according to NC Cooperative Extension Service recommendations and harvested 4 times by stalk position. Residues on cured leaf were quantified by Global Laboratory Services, Inc., in Wilson, NC. Data were analyzed and reported by individual year, location, CPA, and stalk position; with primings 1 and 2 represented in the lower stalk position, priming 3 in the middle stalk position, and priming 4 in the upper stalk position. Generally all CPAs had residues that decrease from the lower stalk to the middle and upper stalk positions. Many results for butralin and flumetralin were below quantifiable limits, regardless of application method. Alternatively, the results for azoxystrobin were relatively high when compared to these compounds. Across all stalk positions and all locations, the highest mean residues observed for azoxystrobin, butralin-BC, butralin-DS, flumetralin-BC, and flumetralin-DS were 13.74, 13.87, 1.55, 3.75, and 2.03 mg/kg, respectively. For those CPAs that have established residue guidelines or tolerances set by CORESTA or USDA (butralin and flumetralin), the threshold was exceeded in at least 1 observation at 1 location when a broadcast application was used. The objective of this work was to determine what a maximum residue might be, not what a residue is expected to be consistently in a given environment.